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Poor sleep is associated with insulin resistance, increased hunger, and weight gain, which might reduce some benefits of GLP-1s [175]

In general, they work by mimicking a hormone that regulates appetite and creates the sensation of feeling full, which has been shown to produce an average reduction of 6 to 25% of body weight in one year, depending on the drug and the patient

We're talking like five to 15% of a person's body weight in a year, and we think these GLP-1 like drugs work in part by traveling to the brain and triggering these molecular switches in parts of the brain that control appetite and hunger, they make people's brains feel full and they eat less

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Consumers expectations about GLP-1 drugs: Economic impact on food system players